Judith Litvin-Daniels

Judith Litvin-Daniels, MS, DrPH
Associate Professor, School of Medicine
Phone: 215-707-2070
Educational Background:
Queens College, CUNY
Flushing, NY
Bachelor of Arts, Biology
Framingham State College
Framingham, MA
Masters, Nutrition
University of North Carolina
DrPH, Nutrition/Biochemistry
Postdoctoral Fellowship Experience:
Weill Cornell University Medical School
Department of Anatomy and Cell Biology
NYC, NY 10065
Mentor: David Bader, Ph.D.
Regulation of cardiac muscle-specific gene expression.
University of Virginia
Department of Biology
Charlottesville, VA 22904
Mentor: Irwin Konigsberg, Ph.D.
Control of myosin heavy chain isoform expression in the quail skeletal muscle system.
University of Virginia Medical School
Department of Anatomy and Cell Biology
Charlottesville, VA 22904
Mentor: Mary Lou King, Ph.D.
The Role of Cell Surface Molecules during Gastrulation in Xenopus laevis.
Professional Activities:
TUSM, MS Year 1, Block 4
Kornberg School of Dentistry, General and Oral Histology
TUSPM: Histology and Embryology
TUSM, Writing Scientific Documents (Graduate)
TUSM, Cell Structure and Function (Graduate)
Associate Director: TUSM, Molecules to Cells (Graduate)
Reading in Cell Biology: Department of Anatomy and Cell Biology, TUSM
Seminars in Cell Biology: Department of Anatomy and Cell Biology, TUSM
Golden Apple Award, 2014
Honorary Chairman National Leadership Award, 2007
Research featured in Trends in Cardiovascular Medicine
NIH Pre-doctoral Trainee Award
USPHS Developmental Biology Training Grant
Fisher PW, Zhao Y, Rico MC, Massicotte VS, Wade CK, Litvin J, Bove GM, Popoff SN, Barbe MF. Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury.
J Cell Commun Signal. 2015 Mar;9(1):37-54. doi: 10.1007/s12079-015-0263-0. Epub 2015 Jan 24.
Jain NX, Barr-Gillespie AE, Clark BD, Kietrys DM, Wade CK, Litvin J, Popoff SN, Barbe MF.  Bone loss from high repetitive high force loading is prevented by ibuprofen treatment.  J Musculoskelet Neuronal Interact. 2014 Mar;14(1):78-94.
Conway S, Fahy J, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron J, Holweg C,
Kudo A.  All authors contributed equally.  The Role of Periostin in Tissue Remodelling in Health and Disease.  Cell Mol Life Sci. 2014 Apr;71(7):1279-88. doi: 10.1007/s00018-013-1494-y. Epub 2013 Oct 22.
Abdelmagid SM, Barr AE, Rico M, Amin M, Litvin J, Popoff SN, Safadi FS, Barbe MF. 
Repetitive Strain Induces Decreases in Grip Strength and Increases in Fibrogenic-
Related Proteins in Skeletal Muscle: Role of Force and Inflammation.  Accepted with
Revisions.  PLoS ONE.  2012.
Contié S, Voorzanger-Rousselot N, Litvin J, Clézardin P, Garnero P. Increased
expression  and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases. Int J Cancer. (2011) Jan 15;128(2):352-60.
Rani, S, Barbe MF, Barr AE, Litvin J, Role of TNF Alpha and PLF in Bone Remodeling in a Rat Model of Repetitive Reaching and Grasping,  Journal of Cellular Physiology 225(1):152-167, 2010
Reddy, H.,  Graña,X., Dhanasekaran,D.,  Litvin,J. and Reddy,E.P.  Requirement of Cdk4 for v-Ha-ras–Induced Breast Tumorigenesis and Activation of the v-ras–Induced Senescence Program by the R24C Mutation  Genes Cancer. 2010 Jan 1;1(1):69-80.
Abedin, Z., Ma, Z., Reddy, P.E. and Litvin, J.  Increased Angiogenesis in Cdk4R24C/R24C:Apc+/Min  Intestinal Tumors Cell Cycle. (2010) Jun 8;9(12).
Chawla R, Procknow JA, Tantravahi RV, Khurana JS, Litvin J, Reddy EP.  Cooperativity of  Cdk4(R24C) and Ras in melanoma development.  Cell Cycle. (2010) Aug 10;9(16).
Contié,S.,  Voorzanger-Rousselot. N, Litvin, J., Bonnet, N., Ferrari, S.,Clézardin,P., and Garnero, P.  Devlopment of a new ELISA for serum periostin: Evaluation of growth-related changes and bisphosphonate treatment in mice.  Calcif Tissue Int. 2010 Jun 22.
Fedorczyk JM, Barr AE, Rani S, Amin M, Gao H, Amin S, Litvin J, Barbe MF.
Exposure dependent increases in IL-1beta, substance P and tendinosis in flexor tendons with upper extremity repetitive strain injury. J Orthop Res. (2009) Sep 9.
Rani S, Barbe MF, Barr AE, Litvin J.  Induction of Periostin-Like-Factor and
Periostin in Forearm Muscle, Tendon and Nerve in an Animal Model of Work-Related usculoskeletal Disorder.  J Histochem Cytochem. 2009 Nov;57(11):1061-73. Epub 2009 Jul 20.
Rani S, Barbe MF, Barr AE, Litvin J.  Periostin-like-factor and Periostin in an
animal model of work-related musculoskeletal disorder.  Bone. (2009) Mar; 44(3):502-12.
Zhu S, Barbe MF, Amin N, Rani S, Popoff SN, Safadi FF, Litvin J.
Immunolocalization of Periostin-Like-Factor and Periostin During Embryogenesis. J Histochem Cytochem. (2008) Apr; 56(4):329-45.
Zhu S, Barbe MF, Liu C, Hadjiargyrou M, Popoff SN, Rani S, Safadi FF, Litvin J. Periostin-like-factor in osteogenesis. J Cell Physiol. (2009) Mar; 218(3):584-92.
Litvin,J., Zhu,S., Kelemen,S., Chen,X., and Auiteri.M.  Expression and function of periostin-like factor in vascular smooth muscle cells.  Am J Physiol Cell Physiol. (2007) May;292(5):C1672-80.
Aksoy MO, Yang Y, Ji R, Reddy PJ, Shahabuddin S, Litvin J, Rogers TJ, Kelsen SG. CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation. Am J Physiol Lung Cell Mol Physiol. (2006)  May;290(5):L909-18. 28.  
Reddy HK, Mettus RV, Rane SG, Grana X, Litvin J, Reddy EP. Cyclin- dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res. (2005) Nov 15;65(22):10174-8.
Litvin, J.,Blagg,A., Mu,A., Mattiwala,S., Montgomery,M.,Berretta, R., Houser,S., and Marguiles,K.  (2006).  Splice variants of Periostin in heart development and disease.  J. Cardiovas. Path. Jan-Feb;15(1):24-32 Corresponding author: J. Litvin 
The Periostin Family of Proteins: Therapeutic Targets for Heart Disease Litvin, J., Zhu,S.,  Norris,R., and Markwald,R. (2005) Anat Rec A Discov Mol Cell Evol Biol.  Dec; 287(2):1205-12. Review.  Corresponding author: J. Litvin
Kelsen SG, Aksoy MO, Yang Y, Shahabuddin S, Litvin J, Safadi F, Rogers TJ. The Chemokine Receptor, CXCR3, and its Splice Variants are Expressed in Human Airway Epithelial Cells. Am J Physiol Lung Cell Mol Physiol. (2004) May 21.
Litvin,J., Selim,A., Montgomery,M., Lehmann,K., Devlin,H., Bednarik,D., and Safadi.F.  (2003).  Expression and Function of Periostin-Isoforms in Bone.  2004 Aug 1;92(5):1044-61.. J. Biol. Chem. Corresponding author: J. Litvin.
Redkar,A.R. and Litvin,J. (2000) A fast and  inexpensive method for raising high specificity polyclonal antibodies in mice.  Technical Tips Online (http://tto.trends.com) T01906.
Redkar, A., M.Montgomery and Litvin,J.  (2001)  Fate mapping of early progenitor cardiac cells using DiI labeling.  Development.  128:2269-2279.
Redkar, A.; Patwardhan, V.; Montgomery, M. and Litvin, J.  (2002)  CMF1, a Rb-binding protein is predominantly associated with early chick heart development.  Gene.  Jan 9;282(1-2):53-64.
Pathwardhan,V.; Fernandez,S.; Montgomery, M.; and Litvin,J.  (1999) Diversification fate of cardaic myocytes is based on their rostro-caudal position. Developmental Dynamics.  218(1):123-136.
Montgomery, M.O., Jiao,Y., Phillips, S.J., Singh, G., Xu, J., Balsara, R. and Litvin,J. (1998) Alterations in sheep fetal right ventricular tissue with induced hemodynamic pressure overload.  Basic Research in Cardiology.  93:192-200.
Toscani,A.; Mettus,R.V.; Coupland,R.; Simpkins,H.; Litvin,J.; Orth,J.; Hatton,K.S. And Reddy,P.K. (1997) A-myb deficient mice exhibit meiotic pachytene arrest in spermatogenesis and defects in breast development. Nature. 386:713-717.
Montgomery,M.O. and Litvin,J. (1997) The cardiac-muscle specific enhancer-promoter of  low/cardiac troponin C binds HMG-2. Gene. 187:159-164.
Latham,K.E.; Litvin, J.; Orth, J.; Mettus,R. and Reddy,P.E. (1996)  Temporal patterns of A-myb and B-myb gene expression during testis development. Oncogene. 13:1161-1168.
Y. Wei, Montgomery,M., Bader,D. And Litvin, J. (1996) Characterization of an “E” box binding protein from the developing avian heart. Development. 122(9):2779-2789.
Montgomery, M., Litvin, J., Gonzalez-Sanchez, A. and Bader,D. (1994) Staging of commitment and differentiation of avian cardiac myocytes. Developmental Biology 164(1) :63-72.
Mettus,R.; Litvin,J.; Wali,A.; Toscani,A.; Latham,K.; Hatton,K. and P.Reddy. (1994) Murine A-myb:evidence for differential splicing and tissue-specific expression. Oncogene. 9:3077-3086.
Litvin, J., Montgomery, M., Goldhamer, D., Emerson, C.P. and Bader, D. (1993) Identification of DNA-binding protein(s) in the developing heart. Developmental Biology. 156(2):409418.
Litvin,J., Montgomery, M., Gonzalez-Sanchez,A. , Bisaha, J. and Bader,D. (1992) Commitment and differentiation of cardiac myocytes. Trends in Cardiovascular Medicine 2(1):27-32.
Litvin, J. and King, M.L. (1990) Developmental expression of regionally specific cell surface antigens in the Xenopus gastrula. Developmental Genetics. 11(1):110-122.
Merrifield, P.A., Sutherland, W.M., Litvin, J. and Konigsberg, LR. (1989) Temporal and tissue-specific expression of myosin heavy chain isoforms in developing and adult avian muscle. Developmental Genetics. 10:372-385.
Litvin, J. and King, M.L. (1989) Cell surface molecules of whole Xenopus embryos identified by radioiodination. Roux’s Archives for Developmental Biology. 198(3):141-147.
Litvin, Judith and King, Mary Lou. (1988) Expression and segregation of nucleoplasmin during development in Xenopus. Development. 102(1): 1-9.
King, M.L., Davis, R., Litvin, J., Klein, S. and Pondel, M. (1986) Localized information in the Xenopus egg and embryo. In: ICN-UCLASymposia on Molecular and Cellular Biology, Vol.21: 97-111.
Litvin, J. and Switzer, B.R. (1988) Pharmacokinetics of ethanol in the guinea pig. Alcoholism: Clinical and Experimental Research. 12(1): 71.
Metcalfe, D.D.; Litvin, J. and Wasserman,S.I. (1982) The isolation, identification and characterization of sulfated glycosaminoglycans synthesized in vitro by human eosinophils. Biochimica et Biophysica Acta.715: 196-204.